Quantitative detection method for snake venom thrombin-like enzyme (SVTLE)

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United States of America Patent

PATENT NO 11584948
SERIAL NO

17389384

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Abstract

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The present invention relates to the technical field of chemical analysis and quantitative detection, in particular to a quantitative detection method for snake venom thrombin-like enzyme (SVTLE) from Agkistrodon halys pallas. The quantitative detection method for the SVTLE includes the following steps of taking a reference substance of marker peptide for the SVTLE from Agkistrodon halys pallas with an amino acid sequence of LDSPVSNSAHIAPLSLPSSAPSVGSVCR, and preparing a series of reference solutions with different concentrations; adding the reference solutions in test solutions respectively for enzymolysis, and then taking a supernatant after enzymolysis as a series of solutions to be detected; and adding the solutions to be detected in a liquid chromatogram-mass spectrometer, and then selecting a qualitative ion pair and a quantitative ion pair to detect contents of marker peptide in the solutions to be detected.

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Patent Owner(s)

  • SHANDONG INSTITUTE FOR FOOD AND DRUG CONTROL; SHANDONG UNIVERSITY; AVANC PHARMACEUTICAL CO.,LTD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chi, Lianli Shandong, CN 6 12
Du, Hongming Liaoning, CN 3 0
Gong, Liping Shandong, CN 4 0
Hang, Baojian Shandong, CN 5 3
Shi, Feng Shandong, CN 154 802
Wang, Congcong Shandong, CN 12 10
Wang, Weijian Shandong, CN 20 203
Xian, Ruiqing Shandong, CN 4 0
You, Pengfei Shandong, CN 1 0

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