C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses

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United States of America Patent

PATENT NO 11584775
APP PUB NO 20190153022A1
SERIAL NO

15760662

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Abstract

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Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

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Patent Owner(s)

  • REATA PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bolton, Gary L Ann Arbor, US 18 393
Caprathe, Bradley William Livonia, US 9 125
Hotema, Martha R Hurst, US 6 15
Jiang, Xin Coppell, US 211 2822
Lee, Chitase Ann Arbor, US 31 220
Roark, William H Ann Arbor, US 15 189
Visnick, Melean Irving, US 67 2162

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