Sensing for automated biological cell injection
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United States of America Patent
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Jan 31, 2023
Grant Date -
May 14, 2020
app pub date -
Oct 31, 2017
filing date -
Oct 31, 2016
priority date (Note) -
In Force
status (Latency Note)
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Abstract
A method of controlling a needle actuator to interact with a cell is provided, the method comprising: providing an actuator comprising a tower, a stage and a needle, wherein the needle is mounted on the stage; applying an electrostatic potential between the tower and the stage to retract the needle; moving the actuator towards the cell; reducing the potential so as to allow the stage and needle to move towards the cell; applying calibration data to detect when the needle has pierced the cell; and reducing the potential further once it has been detected that the needle has pierced the cell. The cell can be a biological cell. The needle can be a micro-needle and the stage can be a micro-stage.
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International Classification(s)
- H01L:SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICE....
- G21K:TECHNIQUES FOR HANDLING PARTICLES OR ELECTROMAGNET....
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- C12M:APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
- G01N:INVESTIGATING OR ANALYSING MATERIALS BY DETERMININ....
- B25J:MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION ....
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