Isoquinolines as inhibitors of HPK1

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United States of America Patent

PATENT NO 11566003
APP PUB NO 20210163417A1
SERIAL NO

16921297

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Abstract

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Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCSOUTH SAN FRANCISCO CA 94080-4990

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cartwright, Matthew W Harlow, GB 13 24
Chan, Bryan Foster City, US 29 896
Drobnick, Joy Daly City, US 15 43
Favor, David Shanghai, CN 12 33
Fong, Kin Chiu Shanghai, CN 26 155
Gancia, Emanuela Harlow, GB 31 131
Gazzard, Lewis Belmont, US 24 134
Good, Andrew Shanghai, CN 36 298
Heffron, Timothy Burlingame, US 34 494
Hu, Yonghan Shanghai, CN 37 137
Lainchbury, Michael Harlow, GB 19 68
Liang, Jun Los Altos Hills, US 203 1123
Madin, Andrew Harlow, GB 58 383
Malhotra, Sushant Burlingame, US 32 96
Mendonca, Rohan Pleasanton, US 22 177
Rajapaksa, Naomi San Mateo, US 8 29
Seward, Eileen Harlow, GB 7 20
Stivala, Craig San Mateo, US 21 67
Tellis, John San Mateo, US 6 23
Wang, Weiru Lafayette, US 30 729
Wei, BinQing Belmont, US 61 563
Zhou, Aihe San Jose, US 29 289

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