Methods of producing lipid-derived compounds and host cells thereof
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United States of America Patent
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Jan 24, 2023
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May 18, 2021
filing date -
May 18, 2021
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Abstract
The present disclosure relates to genetically engineered host cells and methods of producing a lipid-derived compound by employing such host cells. In particular embodiments, the host cell includes a first mutant gene encoding a cytoplasmic tRNA thiolation protein. Optionally, the host cell can include other mutant genes for decreasing fatty alcohol catabolism, decreasing re-importation of secreted fatty alcohol, or displaying other useful characteristics, as described herein.
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