Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
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United States of America Patent
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Jan 10, 2023
Grant Date -
Jun 25, 2020
app pub date -
Dec 13, 2017
filing date -
Dec 15, 2016
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Abstract
The present disclosure provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): (Formula (I)) wherein variables X, Y, R2, R3, R4, R5, R6, and n of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aβ plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
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