Development of a cofilin inhibitor for the treatment of hemorrhagic brain injury-induced neuroinflammation

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United States of America Patent

PATENT NO 11548850
APP PUB NO 20200369603A1
SERIAL NO

16867100

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Abstract

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Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-α, reducing NF-κB, and improving motor deficits in a subject are described.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF TOLEDO2801 W BANCROFT STREET TOLEDO OH 43606

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alaqel, Saleh Toledo, US 1 0
Shah, Zahoor A Toledo, US 1 0
Tillekeratne, Viranga Toledo, US 8 5

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