Dioxoloisoquinolinone derivatives and use thereof
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United States of America Patent
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Dec 27, 2022
Grant Date -
Sep 1, 2022
app pub date -
May 20, 2021
filing date -
Aug 13, 2020
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Abstract
Disclosed are novel dioxoisoquinolinone derivative compounds, pharmaceutically acceptable salts thereof, optical isomers, hydrates, and solvates thereof as well as uses thereof. More specifically, the novel dioxoisoquinolinone derivative compounds, pharmaceutically acceptable salts, optical isomers, hydrates, solvates show inhibition activity of EZH1 (Enhancer of zeste homolog 1) and/or EZH2 (Enhancer of zeste homolog 2) activity. Pharmaceutical compositions containing the compound is also disclosed.
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