Compositions and methods for modulating IL-10 immunostimulatory and anti-inflammatory properties

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11534480
APP PUB NO 20190336582A1
SERIAL NO

16414223

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as “scIL-10” polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1:

description='In-line Formulae' end='lead'(first monomer subunit)-LINKER-(second monomer subunit)   Formula 1description='In-line Formulae' end='tail'

wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
ALKERMES INC852 WINTER STREET WALTHAM MA 02451

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alvarez, Juan C Lincoln, US 11 19
Losey, Heather C Lexington, US 14 14
Moustakas, Demetri T Belmont, US 10 28
Namchuk, Mark N Arlington, US 2 10

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Jun 27, 2026
7.5 Year Payment $3600.00 $1800.00 $900.00 Jun 27, 2030
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jun 27, 2034
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00