Tricin derivatives and compositions thereof for cancer treatment
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United States of America Patent
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Dec 27, 2022
Grant Date -
Aug 20, 2020
app pub date -
Feb 14, 2019
filing date -
Feb 14, 2019
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Abstract
Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-β-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-β-D-glucopyranoside derivatives. Tricin 7-O-β-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-β-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.
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