Enhanced expression of RNA vectors

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United States of America Patent

PATENT NO 11534417
APP PUB NO 20190060262A1
SERIAL NO

16122376

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Abstract

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The present invention relates to methods and compositions for enhancing expression from RNA expression vectores. The invention is based upon the observation that reducing the frequency of the dinucleotide CpG and UpA has a significant effect on expression from such vectores. Aspects of the invention include, amongst others, synthetic RNA vectores, virions, cells, methods of producing vaccines and methods of treatment or immunisation.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHEDINBURGH LOTHIAN EH8 9YL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Simmonds, Peter Edinburgh, GB 13 39

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