Methods and systems for determining personalized t'herapies
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United States of America Patent
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Nov 29, 2022
Grant Date -
Apr 19, 2018
app pub date -
Oct 6, 2017
filing date -
Oct 7, 2016
priority date (Note) -
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Abstract
A method for generating an immune score, the method comprising the steps of: (i) determining a qualitative and/or quantitative assessment of tumor infiltrating lymphocytes in a sample; (ii) determining a qualitative and/or quantitative assessment of T-cell receptor signaling in the sample; (iii) determining a qualitative and/or quantitative assessment of mutation burden in the sample; (iv) generating, using a predictive algorithm, an immune score based on the determined qualitative and/or quantitative assessment of tumor infiltrating lymphocytes, the determined qualitative and/or quantitative assessment of T-cell receptor signaling, and the determined qualitative and/or quantitative assessment of mutation burden.
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