Method for producing amide compound
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United States of America Patent
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Nov 29, 2022
Grant Date -
May 20, 2021
app pub date -
Apr 25, 2019
filing date -
Apr 25, 2018
priority date (Note) -
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Abstract
Provided is a novel method whereby an amide compound can be produced by highly stereoselectively and efficiently performing amidation between a plurality of amino acids and/or peptides. A compound of general formula (3) is synthesized by forming an amide bond between the carboxyl group on the right side of general formula (1) in a compound represented thereby and the amino group on the left side of general formula (2) in a compound represented thereby, in the presence of a Lewis acid catalyst and a silylating agent [in formulae (1), (2) and (3), each symbol has the same meaning as defined in claims].
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