Mutant virus, preparation method therefor and application thereof

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United States of America Patent

PATENT NO 11510974
APP PUB NO 20200268870A1
SERIAL NO

16066283

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Abstract

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The present invention relates to a mutated virus. Said virus can be an influenza virus of human or other animal origin. The present invention also relates to a method for preparing the mutated virus, the method comprising introducing UAG codons into positions upstream of the stop codons per se of one or more genes of a viral genome by reverse genetic techniques. The present invention further relates to uses of the mutated virus, for example, as a live attenuated vaccine, or in replication of controllable and safe virus models, and the like.

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Patent Owner(s)

Patent OwnerAddress
PEKING UNIVERSITY100871 NO 5 THE SUMMER PALACE ROAD BEIJING HAIDIAN DISTRICT BEIJING CITY BEIJING CITY 100871

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Si, Longlong Beijing, CN 9 2
Tian, Zhenyu Beijing, CN 3 7
Xia, Qing Beijing, CN 88 102
Xiao, Sulong Beijing, CN 3 2
Xu, Huan Beijing, CN 41 224
Zhang, Chuanling Beijing, CN 3 3
Zhang, Lihe Beijing, CN 4 4
Zhang, Ziwei Beijing, CN 2 0
Zhou, Demin Beijing, CN 5 13
Zhou, Xueying Beijing, CN 1 0

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