Compositions and methods comprising anti-NRP2 antibodies
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United States of America Patent
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Nov 22, 2022
Grant Date -
Oct 10, 2019
app pub date -
Apr 5, 2019
filing date -
Apr 6, 2018
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Abstract
Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
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