T cell receptors

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11505590
APP PUB NO 20190092834A1
SERIAL NO

16092174

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the germline cancer antigen MAGE A4. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native MAGE A4 TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

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Patent Owner(s)

Patent OwnerAddress
IMMUNOCORE LIMITED101 PARK DRIVE MILTON PARK ABINGDON OXFORDSHIRE OX14 4RY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hayes, Conor Abingdon, GB 12 46
Hibbert, Linda Abingdon, GB 2 6
Liddy, Nathaniel Ross Abingdon, GB 17 118
Mahon, Tara Abingdon, GB 8 11
Raman, Marine Abingdon, GB 2 6

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