Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks
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United States of America Patent
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Nov 15, 2022
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Apr 25, 2019
app pub date -
Oct 22, 2018
filing date -
Oct 20, 2017
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Abstract
A multi-layered microfluidic system featuring tissue chambers for cells in a first layer and a plurality of medium channels for culture medium in a second layer. The tissue chambers fluidly connect to the medium channels such that media flows from the medium channels to the tissue chambers, forming large-scale perfused capillary networks. The capillary networks can undergo angiogenesis and vertical anastomosis. The multi-layered configuration of the system of the present invention allows for flexibility in design.
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