Heterodimeric immunoglobulin constructs and preparation methods thereof

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United States of America Patent

PATENT NO 11498977
APP PUB NO 20190284299A1
SERIAL NO

16337854

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Abstract

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The present invention provides a method for production of stable and highly specific heterodimeric immunoglobulin constructs, e.g., bispecific antibodies, retaining desirable properties of native IgG and lacking undesirable heavy chain-light chain mispairing, that can simultaneously bind two target molecules and are more potent in the treatment of complex diseases.

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Patent Owner(s)

Patent OwnerAddress
BEIJING HANMI PHARMACEUTICAL CO LTDNO 10 TIANZHU WEST ROAD ZONE A TIANZHU AIRPORT INDUSTRIAL ZONE SHUNYI DISTRICT BEIJING 101318 BEIJING CITY BEIJING CITY 101318

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kim, Maengsup Beijing, CN 11 52
Liu, Jiawang Beijing, CN 19 56
Song, Nanmeng Beijing, CN 13 38
Yang, Dongge Beijing, CN 2 7
Yang, Yaping Beijing, CN 25 165

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