Antibody constructs for CDH19 and CD3

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United States of America Patent

PATENT NO 11498964
APP PUB NO 20190016805A1
SERIAL NO

16040927

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Abstract

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The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.

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Patent Owner(s)

Patent OwnerAddress
AMGEN RESEARCH (MUNICH) GMBHMUNICH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chan, Brian Mingtung Port Coquitlam, CA 12 54
Hoffmann, Patrick Munich, DE 69 1097
Jeffries, M Shawn Indianapolis, US 8 24
King, Chadwick Terence North Vancouver, CA 53 1703
Kischel, Roman Munich, DE 43 1316
Kufer, Peter Munich, DE 106 2671
Lemon, Bryan Mountain View, US 13 147
Lutterbüse, Ralf Munich, DE 38 334
Pan, Zheng Fremont, US 23 88
Rau, Doris Munich, DE 49 1124
Raum, Tobias Munich, DE 92 1685
Wesche, Holger San Francisco, US 47 377
Wickramasinghe, Dineli San Francisco, US 14 106
Xiao, Shouhua Foster City, US 14 81

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