Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules

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United States of America Patent

PATENT NO 11478727
APP PUB NO 20200261826A1
SERIAL NO

16848234

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Abstract

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The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

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Patent Owner(s)

Patent OwnerAddress
WATERS TECHNOLOGIES CORPORATION34 MAPLE STREET MILFORD MA 01757

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Birdsall, Robert Westborough, US 12 15
Lauber, Matthew A North Smithfield, US 80 60
Muttikal, Thomas Melvin Blaze Stratford, US 2 2
Nguyen, Jennifer M Uxbridge, US 9 4
Ranbaduge, Nilini Hopkinton, US 3 1
Shion, Henry Hopkinton, US 2 0
Walter, Thomas Ashland, US 109 886
Zhang, Ximo Framingham, US 4 0

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