Method of conveniently producing genetically modified non-human mammal with high efficiency
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United States of America Patent
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Oct 18, 2022
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Dec 14, 2017
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Oct 6, 2015
filing date -
Nov 17, 2014
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Abstract
An object of the present invention is to provide a method of conveniently producing a genetically modified non-human mammal with high efficiency using a CRISPR-Cas9 system and particularly a production method whereby gene knock-in can be achieved with high efficiency regardless of the gene size. The method of producing a genetically modified non-human mammal comprises introducing a Cas9 protein, a crRNA fragment comprising a nucleotide sequence complementary to a target DNA region, and a tracrRNA fragment into a non-human mammalian oocyte to genetically modify the target DNA.
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