Thienopyridine derivatives containing unsaturated aliphatic olefinic bond, preparation method and use thereof

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United States of America Patent

PATENT NO 11466025
APP PUB NO 20200361952A1
SERIAL NO

16640612

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Abstract

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The present invention provides a compound having a structure of formula (I), a preparation method and use thereof, and a pharmaceutical composition containing the compound, wherein R is methyl, ethyl, propyl, vinyl or propenyl. The present invention also provides a crystalline form of the compound, a preparation method and use of the crystalline form, and a pharmaceutical composition comprising the crystalline form. The compounds having the structure of formula (I) of the present invention are present in a solid form, which not only can solve the problem of clopidogrel resistance, but also can solve the problem of severe hemorrhagic side effect and poor safety of some drugs, as well as the problem of poor stability of existing compounds. It can be developed into an ADP receptor antagonist antiplatelet agent with clear therapeutic effect, no resistance and better stability.

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Patent Owner(s)

Patent OwnerAddress
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO LTDTIANJIN 300193

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Changjiang Tianjin, CN 18 4
Li, Lingjun Tianjin, CN 20 75
Li, Yuquan Tianjin, CN 7 5
Liu, Lei Tianjin, CN 843 4906
Liu, Xuyuan Tianjin, CN 3 0
Tang, Lida Tianjin, CN 15 45
Wang, Songhui Tianjin, CN 2 1
Wei, Qunchao Tianjin, CN 1 0
Wei, Wei Tianjin, CN 563 3265
Xu, Weiren Tianjin, CN 12 42
Yan, Hui Tianjin, CN 45 100
Yuan, Jing Tianjin, CN 135 622
Zhang, Shijun Tianjin, CN 38 230
Zheng, Xuemin Tianjin, CN 1 0
Zou, Meixiang Tianjin, CN 8 22

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