Transglycosylation of endo-S and endo-S mutants for antibody glycosylation remodeling
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United States of America Patent
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Oct 4, 2022
Grant Date -
Jan 3, 2019
app pub date -
Jun 29, 2018
filing date -
Jun 29, 2017
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Abstract
The present invention provides for a one-pot enzymatic approach which does not require removal of the enzyme and purification of the intermediate after deglycosylation step, and the Endo-S treatment is able to do both deglycosylation and transglycosylation. The one-pot strategy of the present invention enables chemoenzymatic synthesis of an azido-tagged N-glycoform of monocloncal antibodies which could be further modified through orthogonal chemical ligation for various applications.
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