Aziridinyl and amino dimeric naphthoquinone compounds and use for acute myeloid leukemia

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United States of America Patent

PATENT NO 11459313
APP PUB NO 20200283417A1
SERIAL NO

16344733

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Abstract

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The invention relates to new amino dimeric naphthoquinone compounds with antileukemic activity. Compounds of the invention demonstrated increased aqueous solubility compared to previously available dimeric naphthoquinones and potent nanomolar inhibition of cell survival in AML cells. Preferred compounds contained an aziridine or a secondary amino alcohol pharmacophore.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF MARYLAND BALTIMOREC/O OFFICE OF TECHNOLOGY TRANSFER 620 WEST LEXINGTON STREET 4TH FLOOR BALTIMORE MD 21201

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carter-Cooper, Brandon A Manchester, US 1 0
Emadi, Ashkan Clarksville, US 5 51
Ferraris, Dana Eldersburg, US 7 58
Fletcher, Steven Baltimore, US 24 23
Lapidus, Rena G Baltimore, US 2 0
Sausville, Edward A Edgewater, US 9 88

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