Stable Fc binding protein, method for producing said protein, and antibody adsorbent in which said protein is used

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United States of America Patent

PATENT NO 11427828
APP PUB NO 20200283779A1
SERIAL NO

16606486

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Abstract

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The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn α chain and/or a β2 microglobulin region of a human FcRn β chain by another specific amino acid.

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Patent Owner(s)

Patent OwnerAddress
TOSOH CORPORATION4560 KAISEI-CHO SHUNAN-SHI YAMAGUCHI 7468501

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Endo, Satoshi Kanagawa, JP 85 692
Kizu, Natsuko Kanagawa, JP 2 7
Oe, Seigo Kanagawa, JP 4 9
Terao, Yosuke Kanagawa, JP 9 10
Yamanaka, Naoki Kanagawa, JP 15 61

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