Substituted pyrrolopyridine-derivatives

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United States of America Patent

PATENT NO 11427578
SERIAL NO

16632273

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Abstract

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The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I), in which A, X, R1, R2a, R2b, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

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Patent OwnerAddress
DEUTSCHES KREBSFORSCHUNGSZENTRUMIM NEUENHEIMER FELD 280 HEIDELBERG 69120

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aiguabella, Font Nuria Berlin, DE 2 0
Berndt, Sandra Hohen Neuendorf, DE 31 183
Buchmann, Bernd Hohen Neuendorf, DE 77 344
Carretero, Rafael Heidelberg, DE 9 0
Leder, Gabriele Berlin, DE 6 11
Meier, Robin Michael Wain, DE 6 5
Mowat, Jeffrey Stuart Berlin, DE 5 0
Neuhaus, Roland Berlin, DE 44 180
Offringa, Rienk Heidelberg, DE 35 134
Panknin, Olaf Berlin, DE 27 70
Petersen, Kirstin Berlin, DE 46 259

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