Recombinant FcγRII

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United States of America Patent

PATENT NO 11414475
APP PUB NO 20190233499A1
SERIAL NO

16335519

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Abstract

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The problem to be addressed by the present invention is to provide improved recombinant FcγRIIb and FcγRIIa that do not require refolding and exhibit high productivity and thermal stability, and to provide a method for producing the same. Said problem is solved by improved recombinant FcγRIIb comprising at least the amino acid residues of the extracellular domain of human FcγRIIb (No. 43 to No. 215 in UniProt No. P31994), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 82, 94, 98, 104, 105, or 139 in UniProt No. P31994. Said problem is also solved by improved recombinant FcγRIIa comprising at least the amino acid residues of the extracellular domain of human FcγRIIa (No. 34 to No. 206 in UniProt No. P12318-1), wherein, in said amino acid residues, at least one amino acid substitution has occurred at a position corresponding to No. 73, 85, 89, 95, 96, or 130 in UniProt No. P12318-1.

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Patent Owner(s)

Patent OwnerAddress
TOSOH CORPORATION4560 KAISEI-CHO SHUNAN-SHI YAMAGUCHI 7468501
SAGAMI CHEMICAL RESEARCH INSTITUTE2743-1 HAYAKAWA AYASE-SHI KANAGAWA 252-1193

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Endo, Satoshi Kanagawa, JP 85 692
Hatayama, Kouta Kanagawa, JP 3 6
Ide, Teruhiko Kanagawa, JP 16 87
Ito, Hiroyuki Kanagawa, JP 540 5295
Terao, Yosuke Kanagawa, JP 9 10
Yamanaka, Naoki Kanagawa, JP 15 61

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