Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis

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United States of America Patent

PATENT NO 11384115
APP PUB NO 20210147469A1
SERIAL NO

17060886

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Abstract

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The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS810 VERMONT AVENUE N W WASHINGTON D C DC 20420
VIRGINIA COMMONWEALTH UNIVERSITY800 EAST LEIGH STREET SUITE 3000 RICHMOND VA 23298

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Pandak, William M Richmond, US 7 53
Ren, Shunlin Richmond, US 37 128

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