Lubricating block copolymers and their use as biomimetic boundary lubricants
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United States of America Patent
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Jul 5, 2022
Grant Date -
Aug 1, 2019
app pub date -
Oct 4, 2017
filing date -
Oct 4, 2016
priority date (Note) -
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Abstract
The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.
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