Cellular behaviour monitoring device and method for monitoring changes in cellular behaviour
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United States of America Patent
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Jun 21, 2022
Grant Date -
Nov 5, 2020
app pub date -
May 3, 2019
filing date -
May 3, 2019
priority date (Note) -
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status (Latency Note)
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Abstract
There is described a cellular behaviour monitoring device for monitoring changes in behaviour of cells contained in a sample. The device generally has a well plate with a sample receiving well recessed therein. A filter membrane extends across the well plate and hermetically covers the sample receiving well. The filter membrane has nutrient-permeable and cell-impermeable pores extending through the filter membrane. The device has an electrode layer extending across the filter membrane. The electrode layer has a substrate and behaviour monitoring electrodes spaced-apart from one another in a region of the substrate, with the region being aligned with the sample receiving well. The electrode layer has nutrient-permeable apertures distributed across the region, with at least some of pores are aligned with at least some of the apertures to allow fluid communication therebetween, and nutrient exchange between the sample receiving well and a surrounding environment.
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