PD-1 homing endonuclease variants, compositions, and methods of use

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United States of America Patent

PATENT NO 11365226
APP PUB NO 20210040165A1
SERIAL NO

16330039

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Abstract

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The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

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Patent Owner(s)

  • 2SEVENTY BIO, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gay, Joel Seattle, US 11 163
Jarjour, Jordan Seattle, US 38 161
Mann, Jasdeep Seattle, US 9 9
Zhang, Joy Seattle, US 7 13

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