Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

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United States of America Patent

PATENT NO 11351167
APP PUB NO 20200030323A1
SERIAL NO

16584638

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Abstract

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Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

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Patent Owner(s)

Patent OwnerAddress
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH200 FIRST STREET SW ROCHESTER MN 55905

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baker, Darren J Rochester, US 26 247
Campisi, Judith Berkeley, US 45 387
David, Nathaniel Brisbane, US 43 344
Demaria, Marco Groningen, NL 28 301
Kirkland, James L Rochester, US 50 466
Laberge, Remi-Martin San Francisco, US 42 367
Tchkonia, Tamar Rochester, US 37 340
van, Deursen Jan M A Rochester, US 15 78
Zhu, Yi Rochester, US 173 554

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