Method for preparing (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound

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United States of America Patent

PATENT NO 11345941
APP PUB NO 20210087595A1
SERIAL NO

16805742

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Abstract

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This application relates to biological pharmacy and biochemical engineering, and more particularly to a method of preparing a (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound. This method includes: subjecting a 1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline raceme as a substrate to selective oxidation in the presence of a monoamine oxidase and the non-selective reduction to prepare the (S)-1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline compound, where the monoamine oxidase has an amino acid sequence as shown in SEQ ID NO: 1 or an amino acid sequence having an identity of more than 80% with SEQ ID NO: 1. The kinetic resolution is carried out in the presence of the monoamine oxidase as a catalyst and a reductant, and the resulting product has a high chiral purity.

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Patent Owner(s)

Patent OwnerAddress
FUDAN UNIVERSITYNO 220 HANDAN ROAD YANGPU DISTRICT SHANGHAI 200433 200433

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Fener Shanghai, CN 37 26
Huang, Zedu Shanghai, CN 14 2
Li, Zhining Shanghai, CN 9 24
Wang, Jiaqi Shanghai, CN 39 30

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