Methods and compositions for producing pancreatic beta cells

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United States of America Patent

PATENT NO 11332716
APP PUB NO 20180216076A1
SERIAL NO

15747729

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Abstract

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Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ding, Sheng Orinda, US 111 927
Hebrok, Matthias Belmont, US 9 15
Russ, Holger Andreas San Francisco, US 3 5
Zhu, Saiyong San Francisco, US 21 280

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