PCSK9 antagonists bicyclo-compounds

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United States of America

PATENT NO 11306125
APP PUB NO 20210214395A1
SERIAL NO

17253815

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Abstract

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Disclosed are compounds of Formula I, or a salt thereof cyclic polypeptide of Formula I: Formula I where A, B, E, R4, and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bianchi, Elisabetta Rome, IT 54 263
Branca, Danila Pomezia, IT 22 68
Ding, Fa-Xiang Staten Island, US 43 119
Ingenito, Raffaele Pomezia, IT 22 74
Josien, Hubert B Jersey City, US 38 421
Kerekes, Angela Dawn Plainfield, US 7 23
Santoprete, Alessia Rome, IT 9 42
Tucker, Thomas Joseph North Wales, US 17 43
Walji, Abbas M Lansdale, US 13 33
Wu, Chengwei Ambler, US 19 36
Xiong, Yusheng Plainsboro, US 43 271
Youm, Hyewon Berkeley Heights, US 10 19

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