Method for synthesizing 2-(1-cyclohexenyl)ethylamine

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PATENT NO 11299451
APP PUB NO 20220002224A1
SERIAL NO

16953317

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A method for synthesizing 2-(1-cyclohexenyl)ethylamine. Cyclohexanone (II) is reacted with a Grignard reagent in a first organic solvent to produce 1-vinylcyclohexanol (III), which is then subjected to chlorination and rearrangement reaction with a chlorinating reagent in a second organic solvent in the presence of an organic base to synthesize (2-chloroethylmethylene)cyclolxane (IV). Then (2-chloroethylmethylene)cyclohexane (IV) and urotropine are subjected to quaternization in a third organic solvent to synthesize N-cyclohexylidene ethyl urotropine hydrochloride (V). Finally, the N-cyclohexylidene ethyl urotropine hydrochloride (V) undergoes hydrolysis and rearrangement reaction in a solvent in the presence of an inorganic mineral acid to synthesize 2-(1-cyclohexenyl)ethylamine (I).

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FUDAN UNIVERSITYNO 220 HANDAN ROAD YANGPU DISTRICT SHANGHAI 200433 200433

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Inventor Name Address # of filed Patents Total Citations
Chen, Fener Shanghai, CN 37 26
Cheng, Dang Shanghai, CN 22 0
Huang, Zedu Shanghai, CN 14 2
Jiang, Meifen Shanghai, CN 15 0
Li, Zhining Shanghai, CN 9 24
Tao, Yuan Shanghai, CN 37 67

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