Acoustic separation for bioprocessing
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United States of America
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Apr 5, 2022
Grant Date -
Oct 10, 2019
app pub date -
Jun 25, 2019
filing date -
Jun 25, 2019
priority date (Note) -
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Abstract
A method for separating cells in a biofluid includes pretreating the biofluid by introducing an additive comprising a cell activator, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel to accumulate target cells in a primary stream and non-target cells in a secondary stream. A system for microfluidic cell separation capable of separating target cells from non-target cells in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive comprising a cell activator, and at least one acoustic transducer coupled to the microfluidic separation channel.
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