Method for assessing pain caused by administration of drug solution, and method for selecting drug solution administration
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United States of America
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Mar 29, 2022
Grant Date -
Dec 27, 2018
app pub date -
Aug 31, 2018
filing date -
Aug 31, 2018
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Abstract
A method for assessing pain caused by administration of a drug solution includes: anesthetizing an experimental animal; inserting a measurement electrode into skeletal muscle of the anesthetized experimental animal; puncturing an injection needle into a predetermined part of the anesthetized experimental animal while measuring a myoelectric potential of the skeletal muscle with the measurement electrode; administering a drug solution to the anesthetized experimental animal; and (i) measuring a duration time of the myoelectric response caused by the administration of the drug solution, and/or (ii) measuring an EMG intensity obtained by integrating absolute values of myoelectric potentials during a period from occurrence of the myoelectric response by the administration of the drug solution to disappearance of the myoelectric response.
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