Compositions comprising nucleic acids and methods of using the same
Number of patents in Portfolio can not be more than 2000
United States of America
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Mar 22, 2022
Grant Date -
Jul 5, 2018
app pub date -
Jun 29, 2016
filing date -
Jun 29, 2016
priority date (Note) -
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Abstract
The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or Cas system components. Compositions comprising modified ribonucleic acids have been designed with chemical modification for even higher efficiency as unmodified native strand of sgRNA. Administration of modified ribonucleic acids will allow decreased immune response when administered to a subject, increased stability, increased editing efficiency and facilitated in vivo delivery of sgRNA via various delivery platforms. The disclosure also relates to methods of decreasing off-target effect of CRISPR and a CRISPR complex.
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