Method for producing porous substrate comprising bioabsorbable polymer that contains heparin, porous substrate comprising bioabsorbable polymer that contains heparin, and artificial blood vessel

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United States of America

PATENT NO 11273237
APP PUB NO 20210283314A1
SERIAL NO

16334578

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Abstract

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The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel. The present invention provides a method for producing a porous substrate containing a bioabsorbable polymer and heparin, including: a solution preparing step of preparing a heparin-bioabsorbable polymer solution having heparin uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the heparin, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the heparin; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the heparin to provide a porous substrate containing the heparin.

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Patent Owner(s)

Patent OwnerAddress
GUNZE LIMITED1 ZEZE AONO-CHO AYABE-SHI KYOTO 623-8511

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nakayama, Hidetaka Kyoto, JP 16 144
Shinoka, Toshiharu Tokyo, JP 6 17
Sugiura, Tadahisa Tokyo, JP 1 0
Tara, Shuhei Tokyo, JP 3 3

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