Gene signature for immune therapies in cancer

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11254986
APP PUB NO 20190316203A1
SERIAL NO

15746097

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Abstract

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An immune response subtype of cancer is associated with DNA damage which allows subjects to be stratified for particular therapies including immune therapies which may be combined with DNA damage therapeutics. A method for predicting responsiveness to an antagonist of an inhibitory immune checkpoint and/or an agonist of a stimulatory immune checkpoint comprises determining the expression level of at least one gene selected from Table 2B, 2A or 1 in a sample from the subject. The determined expression level is used to predict responsiveness to an antagonist of an inhibitory immune checkpoint and/or an agonist of a stimulatory immune checkpoint.

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Patent Owner(s)

Patent OwnerAddress
ALMAC DIAGNOSTICS SERVICES LIMITEDALMAC HOUSE 20 SEAGOE INDUSTRIAL ESTATE CRAIGAVON BT63 5QD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bylesjo, Max Belfast, GB 8 142
Davison, Timothy Hillsborough, GB 31 588
Deharo, Steve Lisburn, GB 11 101
Goffard, Nicolas Craigavon, GB 5 34
Harkin, Denis Paul Dromore, GB 13 111
Hill, Laura A Lisburn, GB 9 89
Keating, Katherine E Magherafelt, GB 9 104
Kennedy, Richard Belfast, GB 29 312
O'Donnell, Jude Galbally, GB 9 88
Parkes, Eileen Craigavon, GB 1 3
Patterson, Fionnuala Belfast, GB 9 101
Proutski, Vitali Hillsborough, GB 8 142
Taggart, Laura Craigavon, GB 1 3
Walker, Steven Craigavon, GB 19 102

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