Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes

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United States of America Patent

PATENT NO 11242557
APP PUB NO 20190345544A1
SERIAL NO

16516808

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods, compositions, kits and apparatuses that include a fluid, the fluid containing a ternary complex and Li+, wherein the ternary complex includes a primed template nucleic acid, a polymerase, and a nucleotide cognate for the next correct base for the primed template nucleic acid molecule. As an alternative or addition to Li+, the fluid can contain betaine or a metal ion that inhibits polymerase catalysis such as Ca2+. In addition to Li+, the fluid can contain polyethylenimine (PEI) with or without betaine.

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Patent Owner(s)

  • OMNIOME, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Block, Fabian San Diego, US 8 23
Iyidogan, Pinar San Diego, US 19 128
Liu, Ying Lin San Diego, US 3 21
Middleton, Morassa Mohseni San Diego, US 5 29
Oliphant, Arnold Morgan Hill, US 102 3734
Rohrman, Brittany A La Jolla, US 7 31
Schmidt, Michael James San Diego, US 17 183
Wallen, Mark C San Diego, US 7 44

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