Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
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United States of America Patent
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Feb 8, 2022
Grant Date -
Nov 14, 2019
app pub date -
Jul 19, 2019
filing date -
Apr 26, 2018
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Abstract
Methods, compositions, kits and apparatuses that include a fluid, the fluid containing a ternary complex and Li+, wherein the ternary complex includes a primed template nucleic acid, a polymerase, and a nucleotide cognate for the next correct base for the primed template nucleic acid molecule. As an alternative or addition to Li+, the fluid can contain betaine or a metal ion that inhibits polymerase catalysis such as Ca2+. In addition to Li+, the fluid can contain polyethylenimine (PEI) with or without betaine.
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