Materials and methods to enhance hematopoietic stem cells engraftment procedures

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United States of America Patent

PATENT NO 11241454
APP PUB NO 20170304362A1
SERIAL NO

15592375

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Abstract

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This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that reduce PGE2 biosynthesis or PGE2 receptor antagonists alone, or in combination with other hematopoietic mobilization agents such as AMD3100 and G-CSF, increases the circulation of available HSPCs. Compounds that reduce the cellular synthesis of PGE2 include non-steroidal anti-inflammatory compounds such as indomethacin. Treatment ex vivo of HSPC with an effective amount of PGE2 or at least one of its derivatives such as 16,16-dimethyl prostaglandin E2 (dmPGE2), promotes HSPC engraftment. Similar methods may also be used to increase viral-mediated gene transduction efficacy into HSPC.

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Patent Owner(s)

Patent OwnerAddress
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION351 W 10TH STREET INDIANAPOLIS IN 46202

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hoggatt, Jonathan Somerville, US 13 39
Pelus, Louis M Indianapolis, US 13 109
Singh, Pratibha Indianapolis, US 7 30

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