Method for identifying modulators of G3BP activity

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11237168
APP PUB NO 20200408759A1
SERIAL NO

16453313

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Abstract

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A method of identifying a lead or candidate compound that modulates the activity of GTPase-Activating Protein SH3 Domain-Binding Proteins (G3BP) is provided, which includes determining whether a compound modulates the interaction between the N-terminal Nuclear Transport Factor 2-like (NTF2L) domain of G3BP and FGDF peptide of ubiquitin specific protease 10 (USP10) or non-structural protein 3 (nsP3).

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Patent Owner(s)

Patent OwnerAddress
ST JUDE CHILDREN'S RESEARCH HOSPITAL262 DANNY THOMAS PLACE MEMPHIS TN 38105

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Taosheng Memphis, US 15 12
Lin, Wenwei Memphis, US 11 3
Taylor, J Paul Memphis, US 3 0
Yang, Peiguo Memphis, US 2 0

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