Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same

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United States of America

PATENT NO 11230572
APP PUB NO 20200055901A1
SERIAL NO

16342866

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Abstract

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The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).

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Patent Owner(s)

Patent OwnerAddress
TRIAD NATIONAL SECURITY LLCLOS ALAMOS NATIONAL LABORATORY LC/TAS P O BOX 1663 LOS ALAMOS NM 87545

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barouch, Dan H Brookline, US 32 360
Bricault, Christine Boston, US 3 1
Korber, Bette T Los Alamos, US 43 362
Yusim, Karina Los Alamos, US 7 50

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