Antibodies comprising C-terminal light chain polypeptide extensions and conjugates and methods of use thereof
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United States of America
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Dec 28, 2021
Grant Date -
Jan 12, 2017
app pub date -
Dec 23, 2014
filing date -
Dec 23, 2014
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Abstract
The present disclosure provides light chain polypeptides that include a C-terminal extension, as well as antibodies and antibody conjugates containing such modified light chain polypeptides, where the C-terminal extension includes one or more cysteine residues. Conjugates that include an antibody of the present disclosure conjugated to an agent via the cysteine residue of the C-terminal amino acid extension are also provided. The present disclosure further provides nucleic acids encoding an antibody light chain polypeptide that includes a C-terminal amino acid extension including a cysteine residue. Pharmaceutical compositions including the antibodies or conjugates of the present disclosure are also provided, as are methods of making and use of the modified anti-bodies and conjugates of the present disclosure.
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