Oxygen-responsive bacterial gene switch
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United States of America
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Dec 21, 2021
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Jan 11, 2018
app pub date -
Sep 7, 2017
filing date -
Sep 7, 2017
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Abstract
The invention provided herein relates to sequence determinants that elicit certain levels of gene expression and methods for obtaining engineered ligand-responsive gene switches comprising these sequence determinants. More particularly, the invention provided herein relates to molecular building blocks (i.e., discrete nucleotide sequences), synthetic ligand-responsive gene switches comprising an assembly of these molecular building blocks, and methods of using synthetic ligand-responsive gene switches as customizable and controllable expression systems and sensors.
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