Methods of treatment for bacterial infections
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United States of America Patent
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Dec 7, 2021
Grant Date -
May 28, 2020
app pub date -
Jul 16, 2018
filing date -
Jul 17, 2017
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Abstract
This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
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