Microfluidic chip for the crystallisation of molecules, preparation method, device comprising said chip and method for crystallisation of molecules
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United States of America Patent
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Nov 16, 2021
Grant Date -
Dec 13, 2018
app pub date -
Dec 2, 2016
filing date -
Dec 2, 2015
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Abstract
A microfluidic chip comprising at least one dialysis crystallisation cell. The cell includes: a substrate made of PMMA; a first level including a tank defined at least partially by the substrate and by an outer wall of the cell, the tank being in fluid communication with a channel for inlet and a channel for outlet of a solution allowing the crystallisation method to be implemented; and a second level including a dialysis chamber defined at least partially by an inner wall of the cell without contact with the substrate and by a dialysis membrane forming an interface between the tank and the dialysis chamber, the inner wall including at least one one-piece portion in which the periphery of the membrane is kept sealed.
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