Method for reducing side effects of immune checkpoint control agent

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United States of America Patent

PATENT NO 11168137
APP PUB NO 20170145099A1
SERIAL NO

15316592

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Abstract

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Disclosed is a means for reducing side effects of an immune checkpoint regulator that is used as an anticancer drug or the like. A side-effect reducing agent according to the present invention comprises as an effective ingredient an anti-CD4 antibody having a high cytotoxic activity, or an anti-CD4 antibody or antigen-binding fragment thereof which antibody or fragment comprises a cytotoxic component bound thereto. The anti-CD4 antibody is a human-type chimeric antibody, humanized antibody or human antibody against human CD4. The immune checkpoint regulator may be, for example, an anti-PD-L1 antibody, an antagonistic anti-CTLA-4 antibody, or an agonistic anti-OX40 antibody.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF TOKYO3-1 HONGO 7-CHOME BUNKYO-KU TOKYO 113-8654
IDAC THERANOSTICS INCBUNKYO-KU TOYKO 113-0033

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ishiwata, Yoshiro Tokyo, JP 22 83
Ito, Satoru Tokyo, JP 176 3339
Matsushima, Kouji Tokyo, JP 60 480
Ueha, Satoshi Tokyo, JP 10 23
Yokochi, Shoji Tokyo, JP 15 45

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